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Image Search Results
Journal: ACS chemical neuroscience
Article Title: 10β,17α-Dihydroxyestra-1,4-dien-3-one: A bioprecursor prodrug preferentially producing 17α-estradiol in the brain for targeted neurotherapy
doi: 10.1021/acschemneuro.8b00184
Figure Lengend Snippet: Immobility times in PST (open bars) and wet uterus weights (closed bars) after the s.c. administration of increasing doses of αE2 (30, 100 and 300 μg/kg) or vehicle to OVX CD1 mice. Data are expressed as mean ± standard deviation (SD), n=6 except for the vehicle control group (n=12). Statistically significant difference from control (one-way ANOVA followed by post hoc Dunnett’s tests) is denoted by asterisks; effect size of behavioral response is indicated by Cohen’s d. The co-administration of the ER-antagonist fulvestrant (4 mg/kg body weight) completely reversed the behavioral response and partially reversed uterothrophic effect of 300 μg/kg E2.
Article Snippet:
Techniques: Standard Deviation
Journal: ACS chemical neuroscience
Article Title: 10β,17α-Dihydroxyestra-1,4-dien-3-one: A bioprecursor prodrug preferentially producing 17α-estradiol in the brain for targeted neurotherapy
doi: 10.1021/acschemneuro.8b00184
Figure Lengend Snippet: Immobility times in PST (open bars) and wet uterus weights (closed bars) after the s.c. administration of increasing doses of α-DHED (30, 100 and 300 μg/kg) or vehicle to OVX CD1 mice. Data are expressed as mean ± SD, n=6, except for vehicle control group (n=12). Asterisk denotes statistically significant difference from control (one-way ANOVA followed by post hoc Dunnett’s tests); effect size of behavioral response is indicated by Cohen’s d. The antidepressant-like effect was completely reversible by co-treatment with the ER-antagonist fulvestrant (4 mg/kg body weight).
Article Snippet:
Techniques:
Journal: ACS chemical neuroscience
Article Title: 10β,17α-Dihydroxyestra-1,4-dien-3-one: A bioprecursor prodrug preferentially producing 17α-estradiol in the brain for targeted neurotherapy
doi: 10.1021/acschemneuro.8b00184
Figure Lengend Snippet: Drug concentrations in blood, cortex and uterus after s.c. treatment of OVX CD1 mice (n=4) for 5 days q.d. with vehicle (control), the ER-antagonist fulvestrant (4 mg/kg body weight), αE2 (300 μg/kg body weight) and α-DHED (300 μg/kg body weight), respectively.
Article Snippet:
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